Enzymatic Blockade of the Ubiquitin-Proteasome Pathway | Zendy

Robert Ernst | Zendy; Jasper H.L. Claessen | Zendy; Britta Mueller | Zendy; Sumana Sanyal | Zendy; Eric Spooner | Zendy; Annemarthe G. van der Veen | Zendy; Oktay Kirak | Zendy; Christian Schlieker | Zendy; Wilhelm A. Weihofen | Zendy; Hidde L. Ploegh | Zendy

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Enzymatic Blockade of the Ubiquitin-Proteasome Pathway

Author(s) -

Robert Ernst,

Jasper H.L. Claessen,

Britta Mueller,

Sumana Sanyal,

Eric Spooner,

Annemarthe G. van der Veen,

Oktay Kirak,

Christian Schlieker,

Wilhelm A. Weihofen,

Hidde L. Ploegh

Publication year - 2011

Publication title -

plos biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.127

H-Index - 271

eISSN - 1545-7885

pISSN - 1544-9173

DOI - 10.1371/journal.pbio.1000605

Subject(s) - proteasome , ubiquitin , biology , cytosol , proteolysis , microbiology and biotechnology , endoplasmic reticulum associated protein degradation , enzyme , protein degradation , biochemistry , gene

A viral ubiquitin-specific protease domain blocks cellular protein turnover by preemptive removal of ubiquitin chains and establishes an essential role for deubiquitylation in the removal of unfolded proteins from the endoplasmic reticulum.

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