Break-Induced Replication Is Highly Inaccurate | Zendy

Angela K. Deem | Zendy; Andrea Keszthelyi | Zendy; Tiffany Blackgrove | Zendy; Alexandra Vayl | Zendy; Barbara M. Coffey | Zendy; Ruchi Mathur | Zendy; Andrei Chabes | Zendy; Anna Malkova | Zendy

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Break-Induced Replication Is Highly Inaccurate

Author(s) -

Angela K. Deem,

Andrea Keszthelyi,

Tiffany Blackgrove,

Alexandra Vayl,

Barbara M. Coffey,

Ruchi Mathur,

Andrei Chabes,

Anna Malkova

Publication year - 2011

Publication title -

plos biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.127

H-Index - 271

eISSN - 1545-7885

pISSN - 1544-9173

DOI - 10.1371/journal.pbio.1000594

Subject(s) - biology , dna replication , mutagenesis , dna polymerase , frameshift mutation , genetics , semiconservative replication , proofreading , control of chromosome duplication , dna repair , dna polymerase ii , processivity , dna , microbiology and biotechnology , mutation , gene , polymerase chain reaction , reverse transcriptase

DNA replication initiated by one-ended homologous recombination at a double-strand break is highly inaccurate, as it greatly stimulates frameshift mutations over the entire path of the replication fork.

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