Open AccessLipoprotein Receptor LRP1 Regulates Leptin Signaling and Energy Homeostasis in the Adult Central Nervous System
Author(s) -
Qiang Liu,
Juan Zhang,
Celina Zerbinatti,
Yan Zhan,
Benedict J. Kolber,
Joachim Herz,
Louis J. Muglia,
Guojun Bu
Publication year - 2011
Publication title -
plos biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.127
H-Index - 271
eISSN - 1545-7885
pISSN - 1544-9173
DOI - 10.1371/journal.pbio.1000575
Subject(s) - lrp1 , leptin , leptin receptor , biology , energy homeostasis , endocrinology , medicine , ldl receptor , hypothalamus , receptor , lipoprotein , microbiology and biotechnology , cholesterol , obesity , genetics
Lipoprotein receptor LRP1 play critical roles in lipid metabolism, and this study reveals a novel role for LRP1 in controlling food intake and obesity in the central nervous system of the adult mouse.
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