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The In Vivo Kinetics of RNA Polymerase II Elongation during Co-Transcriptional Splicing
Author(s) -
Yehuda Brody,
Noa Neufeld,
Nicole Bieberstein,
Sébastien Causse,
Eva-Maria Böhnlein,
Karla M. Neugebauer,
Xavier Darzacq,
Yaron ShavTal
Publication year - 2011
Publication title -
plos biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.127
H-Index - 271
eISSN - 1545-7885
pISSN - 1544-9173
DOI - 10.1371/journal.pbio.1000573
Subject(s) - rna polymerase ii , rna splicing , biology , intron , spliceosome , snrnp , transcription (linguistics) , polyadenylation , rna polymerase ii holoenzyme , small nuclear rna , chromatin , exon , precursor mrna , microbiology and biotechnology , exonic splicing enhancer , gene , rna polymerase , polymerase , rna , genetics , gene expression , rna dependent rna polymerase , promoter , linguistics , philosophy
Kinetic analysis shows that RNA polymerase elongation kinetics are not modulated by co-transcriptional splicing and that post-transcriptional splicing can proceed at the site of transcription without the presence of the polymerase.

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