Open AccessHER2 Phosphorylation Is Maintained by a PKB Negative Feedback Loop in Response to Anti-HER2 Herceptin in Breast Cancer
Author(s) -
Merel Gijsen,
Peter King,
Tim Perera,
Peter J. Parker,
Adrian L. Harris,
Banafshé Larijani,
Anthony Kong
Publication year - 2010
Publication title -
plos biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.127
H-Index - 271
eISSN - 1545-7885
pISSN - 1544-9173
DOI - 10.1371/journal.pbio.1000563
Subject(s) - trastuzumab , phosphorylation , protein kinase b , biology , cancer research , breast cancer , monoclonal antibody , cancer , antibody , microbiology and biotechnology , immunology , genetics
A feedback loop maintains HER2 receptor signalling and cell survival in response to Herceptin treatment in HER2-positive breast cancers, but this Herceptin resistance may be bypassed by pan-HER inhibitors.
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