High-Throughput Chemical Screen Identifies a Novel Potent Modulator of Cellular Circadian Rhythms and Reveals CKIα as a Clock Regulatory Kinase | Zendy

Tsuyoshi Hirota | Zendy; Jae Wook Lee | Zendy; Warren G. Lewis | Zendy; Eric Erquan Zhang | Zendy; Ghislaı̀n Breton | Zendy; Xianzhong Liu | Zendy; Michael Garcia | Zendy; Eric C. Peters | Zendy; Jean-Pierre Etchegaray | Zendy; David Traver | Zendy; Peter G. Schultz | Zendy; Steve A. Kay | Zendy

Open Access

High-Throughput Chemical Screen Identifies a Novel Potent Modulator of Cellular Circadian Rhythms and Reveals CKIα as a Clock Regulatory Kinase

Author(s) -

Tsuyoshi Hirota,

Jae Wook Lee,

Warren G. Lewis,

Eric Erquan Zhang,

Ghislaı̀n Breton,

Xianzhong Liu,

Michael Garcia,

Eric C. Peters,

Jean-Pierre Etchegaray,

David Traver,

Peter G. Schultz,

Steve A. Kay

Publication year - 2010

Publication title -

plos biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.127

H-Index - 271

eISSN - 1545-7885

pISSN - 1544-9173

DOI - 10.1371/journal.pbio.1000559

Subject(s) - per1 , circadian rhythm , circadian clock , biology , gene knockdown , microbiology and biotechnology , period (music) , suprachiasmatic nucleus , biochemistry , clock , neuroscience , gene , physics , acoustics

A novel compound “longdaysin” was found to dramatically slow down the speed of the circadian clock through simultaneous inhibition of protein kinases CKIδ, CKIα, and ERK2.

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