S. aureus MscL Is a Pentamer In Vivo but of Variable Stoichiometries In Vitro: Implications for Detergent-Solubilized Membrane Proteins | Zendy

Michael R. Dorwart | Zendy; Robin Wray | Zendy; Chad A. Brautigam | Zendy; Youxing Jiang | Zendy; Paul Blount | Zendy

Open Access

S. aureus MscL Is a Pentamer In Vivo but of Variable Stoichiometries In Vitro: Implications for Detergent-Solubilized Membrane Proteins

Author(s) -

Michael R. Dorwart,

Robin Wray,

Chad A. Brautigam,

Youxing Jiang,

Paul Blount

Publication year - 2010

Publication title -

plos biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.127

H-Index - 271

eISSN - 1545-7885

pISSN - 1544-9173

DOI - 10.1371/journal.pbio.1000555

Subject(s) - pentamer , tetramer , biology , biophysics , mechanosensitive channels , biochemistry , oligomer , random hexamer , membrane , analytical ultracentrifugation , protein structure , sedimentation equilibrium , in vivo , ion channel , crystallography , chemistry , ultracentrifuge , enzyme , receptor , microbiology and biotechnology , organic chemistry

Detergent-induced rearrangements of membrane-protein subunits explain why two MscL channel stoichiometries have been resolved by X-ray crystallography - but S. aureus MscL is truly a pentamer in vivo.

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