Domain Swapping in Allosteric Modulation of DNA Specificity | Zendy

Chad K. Park | Zendy; Hemant Joshi | Zendy; Alka Agrawal | Zendy; M. Imran Ghare | Zendy; E.J. Little | Zendy; Pete Dunten | Zendy; Jurate Bitinaite | Zendy; Nancy C. Horton | Zendy

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Domain Swapping in Allosteric Modulation of DNA Specificity

Author(s) -

Chad K. Park,

Hemant Joshi,

Alka Agrawal,

M. Imran Ghare,

E.J. Little,

Pete Dunten,

Jurate Bitinaite,

Nancy C. Horton

Publication year - 2010

Publication title -

plos biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.127

H-Index - 271

eISSN - 1545-7885

pISSN - 1544-9173

DOI - 10.1371/journal.pbio.1000554

Subject(s) - tetramer , allosteric regulation , dna , biology , restriction enzyme , cleavage (geology) , dimer , endonuclease , protein–dna interaction , dna clamp , biophysics , stereochemistry , biochemistry , enzyme , dna binding protein , chemistry , transcription factor , gene , rna , organic chemistry , fracture (geology) , paleontology , reverse transcriptase

The structure of two DNA-bound SgrAI enzyme dimers is presented, along with mutagenesis experiments supporting a role for this structure in polymer formation and the activation of DNA cleavage by SgrAI.

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