The Leukemia-Associated Mllt10/Af10-Dot1l Are Tcf4/β-Catenin Coactivators Essential for Intestinal Homeostasis | Zendy

Tokameh Mahmoudi | Zendy; Sylvia F. Boj | Zendy; Pantelis Hatzis | Zendy; Vivian Li | Zendy; Nadia Taouatas | Zendy; Robert G. Vries | Zendy; Hans Teunissen | Zendy; Harry Begthel | Zendy; Jeroen Korving | Zendy; Shabaz Mohammed | Zendy; Albert J. R. Heck | Zendy; Hans Clevers | Zendy

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The Leukemia-Associated Mllt10/Af10-Dot1l Are Tcf4/β-Catenin Coactivators Essential for Intestinal Homeostasis

Author(s) -

Tokameh Mahmoudi,

Sylvia F. Boj,

Pantelis Hatzis,

Vivian Li,

Nadia Taouatas,

Robert G. Vries,

Hans Teunissen,

Harry Begthel,

Jeroen Korving,

Shabaz Mohammed,

Albert J. R. Heck,

Hans Clevers

Publication year - 2010

Publication title -

plos biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.127

H-Index - 271

eISSN - 1545-7885

pISSN - 1544-9173

DOI - 10.1371/journal.pbio.1000539

Subject(s) - wnt signaling pathway , biology , zebrafish , tcf4 , catenin , cancer research , axin2 , transcription factor , microbiology and biotechnology , genetics , signal transduction , gene , enhancer

The leukemia-associated Mllt10/Af10 and its partner the histone methyltransferase Dot1l are identified as Tcf4/β-catenin co-activators and shown to be essential for Wnt-driven endogenous gene expression, intestinal development and homeostasis.

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