A Post-Burst Afterdepolarization Is Mediated by Group I Metabotropic Glutamate Receptor-Dependent Upregulation of Cav2.3 R-Type Calcium Channels in CA1 Pyramidal Neurons
Author(s) -
Jin-Yong Park,
Stefan Remy,
Juan A. Varela,
Donald Cooper,
Sungkwon Chung,
HoWon Kang,
JungHa Lee,
Nelson Spruston
Publication year - 2010
Publication title -
plos biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.127
H-Index - 271
eISSN - 1545-7885
pISSN - 1544-9173
DOI - 10.1371/journal.pbio.1000534
Subject(s) - metabotropic glutamate receptor , biology , bursting , neuroscience , metabotropic glutamate receptor 1 , metabotropic receptor , glutamate receptor , voltage dependent calcium channel , metabotropic glutamate receptor 5 , biophysics , calcium , receptor , biochemistry , medicine
The excitability of hippocampal pyramidal neurons is regulated by activation of metabotropic glutamate receptors, an effect that is mediated by modulation of R-type calcium channels.
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