Two Distinct Mechanisms for Actin Capping Protein Regulation—Steric and Allosteric Inhibition | Zendy

Shuichi Takeda | Zendy; Shiho Minakata | Zendy; Ryotaro Koike | Zendy; K. Kawahata | Zendy; Akihiro Narita | Zendy; Masashi Kitazawa | Zendy; Motonori Ota | Zendy; Tohru Yamakuni | Zendy; Yuichiro Maéda | Zendy; Yasushi Nitanai | Zendy

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Two Distinct Mechanisms for Actin Capping Protein Regulation—Steric and Allosteric Inhibition

Author(s) -

Shuichi Takeda,

Shiho Minakata,

Ryotaro Koike,

K. Kawahata,

Akihiro Narita,

Masashi Kitazawa,

Motonori Ota,

Tohru Yamakuni,

Yuichiro Maéda,

Yasushi Nitanai

Publication year - 2010

Publication title -

plos biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.127

H-Index - 271

eISSN - 1545-7885

pISSN - 1544-9173

DOI - 10.1371/journal.pbio.1000416

Subject(s) - allosteric regulation , actin , biology , protein filament , plasma protein binding , biophysics , protein–protein interaction , binding site , steric effects , protein subunit , microbiology and biotechnology , biochemistry , chemistry , stereochemistry , gene , receptor

A crystallographic study reveals the structural basis for regulation by two different inhibitors of the actin capping protein, a critical factor controlling actin-driven cell motility.

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