Open AccessA Large Fraction of Extragenic RNA Pol II Transcription Sites Overlap Enhancers
Author(s) -
Francesca De Santa,
Iros Barozzi,
Flore Mietton,
Serena Ghisletti,
Sara Polletti,
Betsabeh Khoramian Tusi,
Heiko Müller,
Jiannis Ragoussis,
ChiaLin Wei,
Gioacchino Natoli
Publication year - 2010
Publication title -
plos biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.127
H-Index - 271
eISSN - 1545-7885
pISSN - 1544-9173
DOI - 10.1371/journal.pbio.1000384
Subject(s) - enhancer , biology , genetics , transcription (linguistics) , gene , enhancer rnas , chromatin , rna , genome , rna polymerase ii , transcription factor , gene expression , computational biology , promoter , linguistics , philosophy
A substantial fraction of extragenic Pol II transcription sites coincides with transcriptional enhancers, which may be relevant for functional annotation of mammalian genomes.
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