Open AccessNeed-Based Up-Regulation of Protein Levels in Response to Deletion of Their Duplicate Genes
Author(s) -
Alexander DeLuna,
Michael Springer,
Marc W. Kirschner,
Roy Kishony
Publication year - 2010
Publication title -
plos biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.127
H-Index - 271
eISSN - 1545-7885
pISSN - 1544-9173
DOI - 10.1371/journal.pbio.1000347
Subject(s) - biology , genetics , gene , saccharomyces cerevisiae , function (biology) , functional divergence , phenotype , gene duplication , gene dosage , regulation of gene expression , computational biology , genome , gene family , gene expression
Duplicated genes compensate for loss of one of the paralogs by up-regulating the remaining paralog only under growth conditions in which paralog activity is required for survival.
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