ZBED6, a Novel Transcription Factor Derived from a Domesticated DNA Transposon Regulates IGF2 Expression and Muscle Growth | Zendy

Ellen Markljung | Zendy; Lin Jiang | Zendy; Jacob D. Jaffe | Zendy; Tarjei S. Mikkelsen | Zendy; Ola Wallerman | Zendy; Martin Larhammar | Zendy; Xiaolan Zhang | Zendy; Li Wang | Zendy; Veronica Saenz-Vash | Zendy; Andreas Gnirke | Zendy; Anders M. Lindroth | Zendy; Romain Barrès | Zendy; Jie Yan | Zendy; Sara Strömberg | Zendy; Sachinandan De | Zendy; Fredrik Pontén | Zendy; Eric S. Lander | Zendy; Steven A. Carr | Zendy; Juleen R. Zierath | Zendy; Klas Kullander | Zendy; Claes Wadelius | Zendy; Kerstin LindbladToh | Zendy; Göran Andersson | Zendy; Göran Hjälm | Zendy; Leif Andersson | Zendy

Open Access

ZBED6, a Novel Transcription Factor Derived from a Domesticated DNA Transposon Regulates IGF2 Expression and Muscle Growth

Author(s) -

Ellen Markljung,

Lin Jiang,

Jacob D. Jaffe,

Tarjei S. Mikkelsen,

Ola Wallerman,

Martin Larhammar,

Xiaolan Zhang,

Li Wang,

Veronica Saenz-Vash,

Andreas Gnirke,

Anders M. Lindroth,

Romain Barrès,

Jie Yan,

Sara Strömberg,

Sachinandan De,

Fredrik Pontén,

Eric S. Lander,

Steven A. Carr,

Juleen R. Zierath,

Klas Kullander,

Claes Wadelius,

Kerstin LindbladToh,

Göran Andersson,

Göran Hjälm,

Leif Andersson

Publication year - 2009

Publication title -

plos biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.127

H-Index - 271

eISSN - 1545-7885

pISSN - 1544-9173

DOI - 10.1371/journal.pbio.1000256

Subject(s) - biology , c2c12 , transcription factor , chromatin immunoprecipitation , repressor , genetics , transposable element , myogenin , gene silencing , myocyte , dna binding site , regulation of gene expression , microbiology and biotechnology , gene , gene expression , myogenesis , promoter , mutant

This study identifies a previously uncharacterized protein, encoded by a domesticated DNA transposon, called ZBED6 that regulates the expression of the insulin-like growth factor 2 ( IGF2 ) gene, and possibly numerous others, in all placental mammals including human.

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