Open AccessAssembly of the Murine Leukemia Virus Is Directed towards Sites of Cell–Cell Contact
Author(s) -
Jing Jin,
Nathan M. Sherer,
Gisela Heidecker,
David Derse,
Walther Mothes
Publication year - 2009
Publication title -
plos biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.127
H-Index - 271
eISSN - 1545-7885
pISSN - 1544-9173
DOI - 10.1371/journal.pbio.1000163
Subject(s) - biology , retrovirus , cytoplasm , murine leukemia virus , microbiology and biotechnology , contact inhibition , cell , virology , viral entry , virus , cell fusion , cell adhesion , glycoprotein , viral replication , genetics
Applying 4D imaging, this study investigates the mechanism by which cell-cell contact enhances retrovirus spreading and demonstrates that viral budding is highly polarized towards sites of cell-cell contact.
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