Melanopsin as a Sleep Modulator: Circadian Gating of the Direct Effects of Light on Sleep and Altered Sleep Homeostasis in Opn4−/− Mice | Zendy

Jessica W. Tsai | Zendy; Jens Hannibal | Zendy; Grace Hagiwara | Zendy; Damien Colas | Zendy; Élisabeth Ruppert | Zendy; Norman F. Ruby | Zendy; H. Craig Heller | Zendy; Paul Franken | Zendy; Patrice Bourgin | Zendy

Open Access

Melanopsin as a Sleep Modulator: Circadian Gating of the Direct Effects of Light on Sleep and Altered Sleep Homeostasis in Opn4−/− Mice

Author(s) -

Jessica W. Tsai,

Jens Hannibal,

Grace Hagiwara,

Damien Colas,

Élisabeth Ruppert,

Norman F. Ruby,

H. Craig Heller,

Paul Franken,

Patrice Bourgin

Publication year - 2009

Publication title -

plos biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.127

H-Index - 271

eISSN - 1545-7885

pISSN - 1544-9173

DOI - 10.1371/journal.pbio.1000125

Subject(s) - melanopsin , circadian rhythm , biology , sleep (system call) , photopigment , neuroscience , free running sleep , suprachiasmatic nucleus , endocrinology , alertness , medicine , melatonin , circadian clock , light effects on circadian rhythm , retina , computer science , pharmacology , operating system

Analyses in mice deficient for the blue-light-sensitive photopigment melanopsin show that direct effects of light on behavior and EEG depend on the time of day. The data further suggest an unexpected role for melanopsin in sleep homeostasis.

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