Open AccessThe Hierarchy of Exon-Junction Complex Assembly by the Spliceosome Explains Key Features of Mammalian Nonsense-Mediated mRNA Decay
Author(s) -
Niels H. Gehring,
Styliani Lamprinaki,
Matthias W. Hentze,
Andreas E. Kulozik
Publication year - 2009
Publication title -
plos biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.127
H-Index - 271
eISSN - 1545-7885
pISSN - 1544-9173
DOI - 10.1371/journal.pbio.1000120
Subject(s) - spliceosome , rna splicing , biology , microbiology and biotechnology , nonsense mediated decay , genetics , rna binding protein , precursor mrna , exon , messenger rna , rna , gene
Protein complexes deposited on messenger RNAs during their maturation are able to recruit components of a cellular RNA surveillance pathway, thereby linking RNA maturation to subsequent steps in RNA quality control.
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