The Evolution of the DLK1-DIO3 Imprinted Domain in Mammals | Zendy

Carol A. Edwards | Zendy; Andrew J. Mungall | Zendy; Lucy Matthews | Zendy; Edward J. Ryder | Zendy; Dionne Gray | Zendy; Andrew J. Pask | Zendy; Geoff Shaw | Zendy; Jennifer A. Marshall Graves | Zendy; Jane Rogers | Zendy; Ian Dunham | Zendy; Marilyn B. Renfree | Zendy; Anne C. FergusonSmith | Zendy

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The Evolution of the DLK1-DIO3 Imprinted Domain in Mammals

Author(s) -

Carol A. Edwards,

Andrew J. Mungall,

Lucy Matthews,

Edward J. Ryder,

Dionne Gray,

Andrew J. Pask,

Geoff Shaw,

Jennifer A. Marshall Graves,

Jane Rogers,

Ian Dunham,

Marilyn B. Renfree,

Anne C. FergusonSmith

Publication year - 2008

Publication title -

plos biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.127

H-Index - 271

eISSN - 1545-7885

pISSN - 1544-9173

DOI - 10.1371/journal.pbio.0060135

Subject(s) - biology , imprinting (psychology) , genomic imprinting , marsupial , platypus , genetics , monotreme , evolutionary biology , beckwith–wiedemann syndrome , locus (genetics) , gene , dna methylation , zoology , gene expression , taxonomy (biology) , systematics

A comprehensive, domain-wide comparative analysis of genomic imprinting between mammals that imprint and those that do not can provide valuable information about how and why imprinting evolved. The imprinting status, DNA methylation, and genomic landscape of the Dlk1-Dio3 cluster were determined in eutherian, metatherian, and prototherian mammals including tammar wallaby and platypus. Imprinting across the whole domain evolved after the divergence of eutherian from marsupial mammals and in eutherians is under strong purifying selection. The marsupial locus at 1.6 megabases, is double that of eutherians due to the accumulation of LINE repeats. Comparative sequence analysis of the domain in seven vertebrates determined evolutionary conserved regions common to particular sub-groups and to all vertebrates. The emergence of Dlk1-Dio3 imprinting in eutherians has occurred on the maternally inherited chromosome and is associated with region-specific resistance to expansion by repetitive elements and the local introduction of noncoding transcripts including microRNAs and C/D small nucleolar RNAs. A recent mammal-specific retrotransposition event led to the formation of a completely new gene only in the eutherian domain, which may have driven imprinting at the cluster.

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