A Chemoattractant Role for NT-3 in Proprioceptive Axon Guidance | Zendy

Barış Genç | Zendy; P. Hande Özdi̇nler | Zendy; April E. Mendoza | Zendy; Reha S. Erzurumlu | Zendy

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A Chemoattractant Role for NT-3 in Proprioceptive Axon Guidance

Author(s) -

Barış Genç,

P. Hande Özdi̇nler,

April E. Mendoza,

Reha S. Erzurumlu

Publication year - 2004

Publication title -

plos biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.127

H-Index - 271

eISSN - 1545-7885

pISSN - 1544-9173

DOI - 10.1371/journal.pbio.0020403

Subject(s) - biology , axon , dorsal root ganglion , neuroscience , axon guidance , spinal cord , anatomy , sensory system , neurotrophin 3 , proprioception , growth cone , semaphorin , microbiology and biotechnology , neurotrophic factors , receptor , brain derived neurotrophic factor , genetics

Neurotrophin-3 (NT-3) is required for proprioceptive neuron survival. Deletion of the proapoptotic gene Bax in NT-3 knockout mice rescues these neurons and allows for examination of their axon growth in the absence of NT-3 signaling. TrkC-positive peripheral and central axons from dorsal root ganglia follow proper trajectories and arrive in close proximity to their targets but fail to innervate them. Peripherally, muscle spindles are absent and TrkC-positive axons do not enter their target muscles. Centrally, proprioceptive axons branch in ectopic regions of the spinal cord, even crossing the midline. In vitro assays reveal chemoattractant effects of NT-3 on dorsal root ganglion axons. Our results show that survival factor NT-3 acts as a short-distance axon guidance molecule for muscle sensory afferents as they approach their proper targets.

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