Assessment of Motor Symptoms and Functional Impact in Prodromal and Early Huntington Disease | Zendy

Anthony L. Vaccarino | Zendy; Terrence Sills | Zendy; Karen E. Anderson | Zendy; Kevin Biglan | Zendy; Beth Borowsky | Zendy; Joseph Giuliano | Zendy; Mark Guttman | Zendy; Aileen K. Ho | Zendy; Christopher Kennard | Zendy; Peter Kupchak | Zendy; G. Bernhard Landwehrmeyer | Zendy; Andrew W. Michell | Zendy; Jane S. Paulsen | Zendy; Ralf Reilmann | Zendy; Daniël P. van Kammen | Zendy; John Harley Warner | Zendy; Kenneth Evans | Zendy

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Assessment of Motor Symptoms and Functional Impact in Prodromal and Early Huntington Disease

Author(s) -

Anthony L. Vaccarino,

Terrence Sills,

Karen E. Anderson,

Kevin Biglan,

Beth Borowsky,

Joseph Giuliano,

Mark Guttman,

Aileen K. Ho,

Christopher Kennard,

Peter Kupchak,

G. Bernhard Landwehrmeyer,

Andrew W. Michell,

Jane S. Paulsen,

Ralf Reilmann,

Daniël P. van Kammen,

John Harley Warner,

Kenneth Evans

Publication year - 2011

Publication title -

plos currents

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.282

H-Index - 49

ISSN - 2157-3999

DOI - 10.1371/currents.rrn1244

Subject(s) - huntington's disease , disease , multidisciplinary approach , rating scale , scale (ratio) , medicine , variety (cybernetics) , multinational corporation , motor symptoms , clinical psychology , psychology , computer science , developmental psychology , pathology , artificial intelligence , parkinson's disease , social science , physics , quantum mechanics , sociology , political science , law

The Functional Rating Scale Taskforce for pre-Huntington Disease (FuRST-pHD) is a multinational, multidisciplinary initiative with the goal of developing a data-driven, comprehensive, psychometrically sound, rating scale for assessing symptoms and functional ability in prodromal and early Huntington disease (HD) gene expansion carriers. The process involves input from numerous sources to identify relevant symptom domains, including HD individuals, caregivers, and experts from a variety of fields, as well as knowledge gained from the analysis of data from ongoing large-scale studies in HD using existing clinical scales. This is an iterative process in which an ongoing series of field tests in prodromal (prHD) and early HD individuals provides the team with data on which to make decisions regarding which questions should undergo further development or testing and which should be excluded. We report here the development and assessment of the first iteration of interview questions aimed to assess functional impact of motor manifestations in prHD and early HD individuals.

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