Circadian Abnormalities in Motor Activity in a BAC Transgenic Mouse Model of Huntington’s Disease | Zendy

Stephen Oakeshott | Zendy; Fuat Balcı | Zendy; Igor Filippov | Zendy; Carol A. Murphy | Zendy; Russell G. Port | Zendy; David Connor | Zendy; Ahmad Paintdakhi | Zendy; Joseph LeSauter | Zendy; Liliana Menalled | Zendy; Sylvie Ramboz | Zendy; Seung Kwak | Zendy; David Howland | Zendy; Rae Silver | Zendy; Dani Brunner | Zendy

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Circadian Abnormalities in Motor Activity in a BAC Transgenic Mouse Model of Huntington’s Disease

Author(s) -

Stephen Oakeshott,

Fuat Balcı,

Igor Filippov,

Carol A. Murphy,

Russell G. Port,

David Connor,

Ahmad Paintdakhi,

Joseph LeSauter,

Liliana Menalled,

Sylvie Ramboz,

Seung Kwak,

David Howland,

Rae Silver,

Dani Brunner

Publication year - 2011

Publication title -

plos currents

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.282

H-Index - 49

ISSN - 2157-3999

DOI - 10.1371/currents.rrn1225

Subject(s) - circadian rhythm , huntington's disease , disease , genetically modified mouse , neuroscience , sleep (system call) , medicine , transgene , bioinformatics , endocrinology , biology , genetics , gene , computer science , operating system

Huntington’s disease (HD) is a progressive neurodegenerative disease marked by psychiatric and motor problems. Recently, these findings have been extended to deficits in sleep and circadian function that can be observed in HD patients and in HD mouse models, with abnormal sleep patterns correlating with symptom severity in patients. Here, we studied the behavior of the BAC HD mouse model using an 24/7 automated system; the results indicate significant lengthening of the circadian period in the mutant mice. These results reinforce previous findings in HD models and symptomatic HD patients, indicating that circadian dysfunction is a core feature of HD.

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