Genetic risk profiling for prediction of type 2 diabetes
Author(s) -
Raluca Mihăescu,
James B. Meigs,
Eric J.G. Sijbrands,
A. Cecile J.W. Janssens
Publication year - 2011
Publication title -
plos currents
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.282
H-Index - 49
ISSN - 2157-3999
DOI - 10.1371/currents.rrn1208
Subject(s) - single nucleotide polymorphism , type 2 diabetes , medicine , disease , bioinformatics , candidate gene , computational biology , profiling (computer programming) , genetic association , genome wide association study , diabetes mellitus , genetics , gene , computer science , biology , genotype , endocrinology , operating system
Type 2 diabetes (T2D) is a common disease caused by a complex interplay between many genetic and environmental factors. Candidate gene studies and recent collaborative genome-wide association efforts revealed at least 38 common single nucleotide polymorphisms (SNPs) associated with increased risk of T2D. Genetic testing of multiple SNPs is considered a potentially useful tool for early detection of individuals at high diabetes risk leading to improved targeting of preventive interventions.
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