KIF6 p.Trp719Arg Testing to Assess Risk of Coronary Artery Disease and/or Statin Response | Zendy

Diane AllinghamHawkins | Zendy; Andrew Lea | Zendy; Susan Levine | Zendy

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KIF6 p.Trp719Arg Testing to Assess Risk of Coronary Artery Disease and/or Statin Response

Author(s) -

Diane AllinghamHawkins,

Andrew Lea,

Susan Levine

Publication year - 2010

Publication title -

plos currents

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.282

H-Index - 49

ISSN - 2157-3999

DOI - 10.1371/currents.rrn1191

Subject(s) - coronary artery disease , single nucleotide polymorphism , medicine , genome wide association study , snp , statin , cad , disease , bioinformatics , risk factor , atherosclerotic cardiovascular disease , genetic association , genetics , gene , biology , genotype , biochemistry

Coronary artery disease (CAD) is a leading cause of death worldwide and in the United States it is responsible for more than 500,000 deaths each year. Genome-wide association studies (GWAS) have revealed connections between a number of common single nucleotide polymorphisms (SNPs) and CAD and other cardiovascular diseases. The p.Trp719Arg SNP in the kinesin-like family 6 (KIF6) gene has recently been reported as a potential risk factor for CAD as well as a predictor of response to statin therapy.

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