Rapid Development of an Efficacious Swine Vaccine for Novel H1N1 | Zendy

Ryan Vander Veen | Zendy; Kurt I. Kamrud | Zendy; Mark Mogler | Zendy; Alan T. Loynachan | Zendy; Jerry McVicker | Zendy; Peter Berglund | Zendy; Gary Owens | Zendy; Sarah Timberlake | Zendy; Whitney Lewis | Zendy; Jonathan Smith | Zendy; DL Hank Harris | Zendy

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Rapid Development of an Efficacious Swine Vaccine for Novel H1N1

Author(s) -

Ryan Vander Veen,

Kurt I. Kamrud,

Mark Mogler,

Alan T. Loynachan,

Jerry McVicker,

Peter Berglund,

Gary Owens,

Sarah Timberlake,

Whitney Lewis,

Jonathan Smith,

DL Hank Harris

Publication year - 2009

Publication title -

plos currents

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.282

H-Index - 49

ISSN - 2157-3999

DOI - 10.1371/currents.rrn1123

Subject(s) - virology , hemagglutinin (influenza) , alphavirus , vaccination , recombinant dna , influenza vaccine , medicine , replicon , strain (injury) , viral shedding , antibody , biology , virus , immunology , dna , biochemistry , genetics , plasmid , gene

Recombinant hemagglutinin (HA) from a novel H1N1 influenza strain was produced using an alphavirus replicon expression system. The recombinant HA vaccine was produced more rapidly than traditional vaccines, and was evaluated as a swine vaccine candidate at different doses in a challenge model utilizing the homologous influenza A/California/04/2009 (H1N1) strain. Vaccinated animals showed significantly higher specific antibody response, reduced lung lesions and viral shedding, and higher average daily gain when compared to non-vaccinated control animals. These data demonstrate that the swine vaccine candidate was efficacious at all of the evaluated doses.

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