Green tea catechins inhibit the endonuclease activity of influenza A virus RNA polymerase | Zendy

Takashi Kuzuhara | Zendy; Yuma Iwai | Zendy; Hironobu Takahashi | Zendy; Dai Hatakeyama | Zendy; Noriko Echigo | Zendy

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Green tea catechins inhibit the endonuclease activity of influenza A virus RNA polymerase

Author(s) -

Takashi Kuzuhara,

Yuma Iwai,

Hironobu Takahashi,

Dai Hatakeyama,

Noriko Echigo

Publication year - 2009

Publication title -

plos currents

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.282

H-Index - 49

ISSN - 2157-3999

DOI - 10.1371/currents.rrn1052

Subject(s) - endonuclease , polymerase , virus , catechin , influenza a virus , rna polymerase , virology , rna dependent rna polymerase , rna , chemistry , computational biology , enzyme , biochemistry , biology , polyphenol , gene , antioxidant

The influenza A RNA polymerase possesses endonuclease activity to digest the host mRNA. Thus this endonuclease domain can be a target of anti-influenza A virus drug. Here we report that green tea catechins inhibit this viral endonuclease activity and that their galloyl group is important for their function. Docking simulations revealed that catechins with galloyl group fit well into the active pocket of the endonuclease domain to enable stable binding. Our results provide useful data that make it possible to refine and optimize catechin-based drug design more readily for stability.

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