Heat-induced Antigen Retrieval: What Are We Retrieving? | Zendy

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Heat-induced Antigen Retrieval: What Are We Retrieving?

Author(s) -

Thomas Boenisch

Publication year - 2006

Publication title -

journal of histochemistry and cytochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.971

H-Index - 124

eISSN - 1551-5044

pISSN - 0022-1554

DOI - 10.1369/jhc.6p6945.2006

Subject(s) - antigen retrieval , antigen , focus (optics) , fixation (population genetics) , immune system , antibody , immunohistochemistry , computer science , chemistry , immunology , biology , biochemistry , physics , optics , gene

Of all molecular aspects lost and recovered during formalin fixation and antigen retrieval, respectively, electrostatic charges have probably received the least attention. This review will focus on our work during the past 7 years. It strongly supports the tenet that electrostatic charges, i.e., net negative on antigens and net positive on antibodies, play an important part in immune reactions and therefore should be given greater attention when focusing on quality control in immunohistochemistry.

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