New Immortalized Cell Lines of Patients With Small Supernumerary Marker Chromosome | Zendy

Holger Tönnies | Zendy; Joanna Pietrzak | Zendy; Ewa Bocian | Zendy; Kay MacDermont | Zendy; Alma Kuechler | Zendy; Britta Belitz | Zendy; Udo Trautmann | Zendy; Angela Schmidt | Zendy; Berndt Schulze | Zendy; Laura Rodríguez | Zendy; Franz Binkert | Zendy; Catharine Yardin | Zendy; Nadezda Kosyakova | Zendy; Marianne Volleth | Zendy; Hasmik Mkrtchyan | Zendy; Isolde Schreyer | Zendy; Ferdinand von Eggeling | Zendy; Anja Weise | Zendy; Kristin Mrasek | Zendy; Thomas Liehr | Zendy

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New Immortalized Cell Lines of Patients With Small Supernumerary Marker Chromosome

Author(s) -

Holger Tönnies,

Joanna Pietrzak,

Ewa Bocian,

Kay MacDermont,

Alma Kuechler,

Britta Belitz,

Udo Trautmann,

Angela Schmidt,

Berndt Schulze,

Laura Rodríguez,

Franz Binkert,

Catharine Yardin,

Nadezda Kosyakova,

Marianne Volleth,

Hasmik Mkrtchyan,

Isolde Schreyer,

Ferdinand von Eggeling,

Anja Weise,

Kristin Mrasek,

Thomas Liehr

Publication year - 2007

Publication title -

journal of histochemistry and cytochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.971

H-Index - 124

eISSN - 1551-5044

pISSN - 0022-1554

DOI - 10.1369/jhc.6a7161.2007

Subject(s) - small supernumerary marker chromosome , supernumerary , uniparental disomy , biology , marker chromosome , genetics , karyotype , comparative genomic hybridization , genetic marker , chromosome , fluorescence in situ hybridization , microbiology and biotechnology , gene , anatomy

Sixteen newly established cell lines with small supernumerary marker chromosomes (sSMC) derived from chromosomes 1, 2, 4, 6, 7, 8, 14, 15, 16, 18, 19, 21, and 22 are reported. Two sSMC are neocentric and derived from 15q24.1-qter and 2q35-q36, respectively. Two further cases each present with two sSMC of different chromosomal origin. sSMC were characterized by multicolor fluorescence in situ hybridization for their chromosomal origin and genetic content. Moreover, uniparental disomy of the sister chromosomes of the sSMC was excluded in all nine cases studied for that reason. The 16 cases provide information to establish a refined genotype-phenotype correlation of sSMC and are available for future studies.

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