Presence of Collagen IV in the Ciliary Zonules of the Human Eye | Zendy

Leonoor I. Los | Zendy; Roelofje J. van der Worp | Zendy; Marja J.A. van Luyn | Zendy; Johanna M. M. Hooymans | Zendy

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Presence of Collagen IV in the Ciliary Zonules of the Human Eye

Author(s) -

Leonoor I. Los,

Roelofje J. van der Worp,

Marja J.A. van Luyn,

Johanna M. M. Hooymans

Publication year - 2004

Publication title -

journal of histochemistry and cytochemistry

Language(s) - English

Resource type - Journals

eISSN - 1551-5044

pISSN - 0022-1554

DOI - 10.1369/jhc.4a6267.2004

Subject(s) - polyclonal antibodies , fibril , immunohistochemistry , monoclonal antibody , chemistry , ultimate tensile strength , biophysics , antibody , anatomy , materials science , biology , immunology , composite material , biochemistry

The ciliary zonules of the eye are composed of fibrillar and non-fibrillar components. Fibrils provide tensile strength and elasticity, whereas non-fibrillar components serve as a coating surrounding the fibrils. This coating behaves as a barrier to macromolecules. The present light and transmission electron microscopic (LM and TEM) study identified collagen IV as a novel component of this coating. Collagen IV was demonstrated by pre-embedding and postembedding immunohistochemical (IHC) techniques using monoclonal and polyclonal antibodies. The specificity of the polyclonal anticollagen IV antibody was verified by ELISA. (J Histochem Cytochem 52:789–795, 2004)

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