Open AccessThe Role of Chondroitin Sulfate Proteoglycans in Nervous System Development
Author(s) -
Caitlin P. Mencio,
Rowan K. Hussein,
Panpan Yu,
Herbert M. Geller
Publication year - 2020
Publication title -
journal of histochemistry and cytochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.971
H-Index - 124
eISSN - 1551-5044
pISSN - 0022-1554
DOI - 10.1369/0022155420959147
Subject(s) - synapse formation , neuroscience , nervous system , chondroitin sulfate , neural development , axon guidance , biology , brain development , process (computing) , microbiology and biotechnology , synapse , anatomy , computer science , axon , biochemistry , glycosaminoglycan , gene , operating system
The orderly development of the nervous system is characterized by phases of cell proliferation and differentiation, neural migration, axonal outgrowth and synapse formation, and stabilization. Each of these processes is a result of the modulation of genetic programs by extracellular cues. In particular, chondroitin sulfate proteoglycans (CSPGs) have been found to be involved in almost every aspect of this well-orchestrated yet delicate process. The evidence of their involvement is complex, often contradictory, and lacking in mechanistic clarity; however, it remains obvious that CSPGs are key cogs in building a functional brain. This review focuses on current knowledge of the role of CSPGs in each of the major stages of neural development with emphasis on areas requiring further investigation:
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom