The Role of Glypicans in Cancer Progression and Therapy | Zendy

Nan Li | Zendy; Madeline R. Spetz | Zendy; Mitchell Ho | Zendy

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The Role of Glypicans in Cancer Progression and Therapy

Author(s) -

Nan Li,

Madeline R. Spetz,

Mitchell Ho

Publication year - 2020

Publication title -

journal of histochemistry and cytochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.971

H-Index - 124

eISSN - 1551-5044

pISSN - 0022-1554

DOI - 10.1369/0022155420933709

Subject(s) - extracellular matrix , heparan sulfate , carcinogenesis , biology , cancer , extracellular , morphogenesis , cell , cancer research , microbiology and biotechnology , motility , cell growth , cancer cell , receptor , metastasis , immunology , biochemistry , genetics , gene

Glypicans are a family of heparan sulfate proteoglycans that are attached to the cell membrane via a glycosylphosphatidylinositol anchor. Glypicans interact with multiple ligands, including morphogens, growth factors, chemokines, ligands, receptors, and components of the extracellular matrix through their heparan sulfate chains and core protein. Therefore, glypicans can function as coreceptors to regulate cell proliferation, cell motility, and morphogenesis. In addition, some glypicans are abnormally expressed in cancers, possibly involved in tumorigenesis, and have the potential to be cancer-specific biomarkers. Here, we provide a brief review focusing on the expression of glypicans in various cancers and their potential to be targets for cancer therapy.

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