Fluorescence Correlation Spectroscopy: A Review of Biochemical and Microfluidic Applications | Zendy

Yu Tian | Zendy; Michelle Martínez | Zendy; Dimitri Pappas | Zendy

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Fluorescence Correlation Spectroscopy: A Review of Biochemical and Microfluidic Applications

Author(s) -

Yu Tian,

Michelle Martínez,

Dimitri Pappas

Publication year - 2011

Publication title -

applied spectroscopy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.415

H-Index - 110

eISSN - 1943-3530

pISSN - 0003-7028

DOI - 10.1366/10-06224

Subject(s) - fluorescence correlation spectroscopy , fluorescence , spectroscopy , fluorescence spectroscopy , microscopy , microfluidics , fluorescence cross correlation spectroscopy , confocal , dynamic light scattering , chemistry , materials science , analytical chemistry (journal) , optics , nanotechnology , physics , chromatography , nanoparticle , quantum mechanics

Over the years fluorescence correlation spectroscopy (FCS) has proven to be a useful technique that has been utilized in several fields of study. Although FCS initially suffered from poor signal-to-noise ratios, the incorporation of confocal microscopy has overcome this drawback and transformed FCS into a sensitive technique with high figures of merit. In addition, tandem methods have evolved to include dual-color cross-correlation, total internal reflection fluorescence correlation, and fluorescence lifetime correlation spectroscopy combined with time-correlated single-photon counting. In this review, we discuss several applications of FSC for biochemical, microfluidic, and cellular investigations.

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