Self calibration iso-pathlength point in cylindrical tissue geometry: solution of steady-state photon diffusion based on the extrapolated zero-boundary | Zendy

Hamootal Duadi | Zendy; Daqing Piao | Zendy; Dror Fixler | Zendy

Open Access

Self calibration iso-pathlength point in cylindrical tissue geometry: solution of steady-state photon diffusion based on the extrapolated zero-boundary

Author(s) -

Hamootal Duadi,

Daqing Piao,

Dror Fixler

Publication year - 2018

Publication title -

osa continuum

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.592

H-Index - 8

ISSN - 2578-7519

DOI - 10.1364/osac.2.000092

Subject(s) - monte carlo method , diffusion , photon diffusion , radius , optics , photon transport in biological tissue , steady state (chemistry) , calibration , boundary (topology) , boundary value problem , point source , surface (topology) , photon , attenuation coefficient , work (physics) , point (geometry) , physics , geometry , mathematical analysis , chemistry , mathematics , computer science , light source , statistics , dynamic monte carlo method , quantum mechanics , direct simulation monte carlo , computer security , thermodynamics

Near-infrared optical techniques permit tissue diagnosis by surface measurement. However, the geometrical shape of this interface profiles the intensity of the surface measurement, which is found to have an iso-pathlength (IPL) point allowing for absorption identification independent of tissue scattering. The IPL point was projected in Monte Carlo (MC) simulation, validated experimentally in cylindrical tissues, but remains under-appreciated through analytical approaches. In this work, we present an analytical solution of an IPL point for steady-state diffusion based on the extrapolated zero-boundary condition. The same IPL points were found when comparing this solution to 3-D MC simulations for a tissue radius range of 5-8mm.

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