Multiharmonic-generation biopsy of skin | Zendy

ChiKuang Sun | Zendy; ChengChi Chen | Zendy; ShiWei Chu | Zendy; Tsung-Han Tsai | Zendy; YungChih Chen | Zendy; Bai-Ling Lin | Zendy

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Multiharmonic-generation biopsy of skin

Author(s) -

ChiKuang Sun,

ChengChi Chen,

ShiWei Chu,

Tsung-Han Tsai,

YungChih Chen,

Bai-Ling Lin

Publication year - 2003

Publication title -

optics letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.524

H-Index - 272

eISSN - 1071-2763

pISSN - 0146-9592

DOI - 10.1364/ol.28.002488

Subject(s) - biopsy , phototoxicity , optics , fluorescence , focus (optics) , materials science , pathology , medicine , physics , chemistry , biochemistry , in vitro

Because it avoids the in-focus photodamage and phototoxicity problem of two-photon-fluorescence excitation, multiharmonic-generation biopsy based on a 1200-1300-nm light source could provide a truly noninvasive and highly penetrative optical sectioning of skin. We study multiharmonic-generation biopsy of fixed mouse skin. Our preliminary study suggests that this technique could provide submicrometer-resolution deep-tissue noninvasive biopsy images in skin without the use of fluorescence and exogenous markers.

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