Differential diffuse optical tomography | Zendy

Vasilis Ntziachristos | Zendy; Britton Chance | Zendy; Arjun G. Yodh | Zendy

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Differential diffuse optical tomography

Author(s) -

Vasilis Ntziachristos,

Britton Chance,

Arjun G. Yodh

Publication year - 1999

Publication title -

optics express

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.394

H-Index - 271

ISSN - 1094-4087

DOI - 10.1364/oe.5.000230

Subject(s) - diffuse optical imaging , optics , contrast (vision) , photon diffusion , transmission (telecommunications) , diffuse reflection , diffusion , optical tomography , tomography , wavelength , inverse problem , attenuation coefficient , absorption (acoustics) , physics , computer science , mathematics , mathematical analysis , telecommunications , light source , thermodynamics

We formulate a perturbative solution for the heterogeneous diffusion equation which demonstrates how to use differential changes in diffuse light transmission to construct images of tissue absorption changes following contrast agent administration. The analysis exposes approximations leading to an intuitive and simplified inverse algorithm, shows explicitly why transmission geometries are less susceptible to error than the remission geometries, and why differential measurements are less susceptible to surface artifacts. These ideas about differential diffuse optical tomography are not only applicable to tumor detection and characterization using contrast agents, but also to functional activation studies with or without contrast agents and multiple-wavelength measurements.

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