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High resolution corneal and single pulse imaging with line field spectral domain optical coherence tomography
Author(s) -
Samuel Lawman,
Yue Dong,
Bryan M. Williams,
Vito Romano,
Stephen B. Kaye,
Simon Harding,
Colin E. Willoughby,
Yaochun Shen,
Yalin Zheng
Publication year - 2016
Publication title -
optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 271
ISSN - 1094-4087
DOI - 10.1364/oe.24.012395
Subject(s) - optical coherence tomography , optics , physics , preclinical imaging , image resolution , coherence (philosophical gambling strategy) , materials science , quantum mechanics , microbiology and biotechnology , in vivo , biology
We report the development of a Spectral Domain Line Field Optical Coherence Tomography (LF-OCT) system, using a broad bandwidth and spatial coherent Super-Continuum (SC) source. With conventional quasi-Continuous Wave (CW) setup we achieve axial resolutions up to 2.1 μm in air and 3D volume imaging speeds up to 213 kA-Scan/s. Furthermore, we report the use of a single SC pulse, of 2 ns duration, to temporally gate an OCT B-Scan image of 70 A-Scans. This is the equivalent of 35 GA-Scans/s. We apply the CW setup for high resolution imaging of the fine structures of a human cornea sample ex-vivo. The single pulse setup is applied to imaging of a coated pharmaceutical tablet. The fixed pattern noise due to spectral noise is removed by subtracting the median magnitude A-Scan. We also demonstrate that the Fourier phase can be used to remove aberration caused artefacts.

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