Open AccessEvaluation of breast tumor margins in vivo with intraoperative photoacoustic imaging
Author(s) -
Lei Xi,
Stephen R. Grobmyer,
Lei Wu,
Ruimin Chen,
Guangyin Zhou,
Luke G. Gutwein,
Jingjing Sun,
Wenjun Liao,
Qifa Zhou,
Huikai Xie,
Huabei Jiang
Publication year - 2012
Publication title -
optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 271
ISSN - 1094-4087
DOI - 10.1364/oe.20.008726
Subject(s) - photoacoustic imaging in biomedicine , preclinical imaging , breast cancer , breast tumor , photoacoustic tomography , optical coherence tomography , medicine , breast imaging , radiology , medical imaging , breast conserving surgery , in vivo , biomedical engineering , mammography , tomography , cancer , optics , mastectomy , physics , microbiology and biotechnology , biology
The use of photoacoustic effect is a promising approach for biomedical imaging in living tissues. Photoacoustic tomography (PAT) has been demonstrated to image breast cancer, brain vasculature, arthritis and seizure focus owing to its rich optical contrast and high resolution in a single imaging modality. Here we report a microelectromechanical systems (MEMS)-based intraoperative PAT (iPAT) technique, and demonstrate its ability to accurately map tumors in three-dimension and to inspect the completeness of tumor resection during surgery in a tumor-bearing mouse model. The MEMS imaging probe is small and has the potential to be conveniently used to guide surgical resection of tumors in the breast.
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