Dual-beam-scan Doppler optical coherence angiography for birefringence-artifact-free vasculature imaging | Zendy

Shuichi Makita | Zendy; Franck Jaillon | Zendy; Masahiro Yamanari | Zendy; Yoshiaki Yasuno | Zendy

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Dual-beam-scan Doppler optical coherence angiography for birefringence-artifact-free vasculature imaging

Author(s) -

Shuichi Makita,

Franck Jaillon,

Masahiro Yamanari,

Yoshiaki Yasuno

Publication year - 2012

Publication title -

optics express

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.394

H-Index - 271

ISSN - 1094-4087

DOI - 10.1364/oe.20.002681

Subject(s) - birefringence , optical coherence tomography , optics , materials science , doppler effect , preclinical imaging , biomedical engineering , in vivo , physics , medicine , astronomy , microbiology and biotechnology , biology

Dual-beam-scan Doppler optical coherence angiography (DB-OCA) enables high-speed, high-sensitivity blood flow imaging. However, birefringence of biological tissues is an obstacle to vasculature imaging. Here, the influence of polarization and birefringence on DB-OCA imaging was analyzed. A DB-OCA system without birefringence artifact has been developed by introducing a Faraday rotator. The performance was confirmed in vitro using chicken muscle and in vivo using the human eye. Birefringence artifacts due to birefringent tissues were suppressed. Micro-vasculatures in the lamina cribrosa and nerve fiber layer of human eyes were visualized in vivo. High-speed and high-sensitivity micro-vasculature imaging involving birefringent tissues is available with polarization multiplexing DB-OCA.

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