Whispering gallery mode bio-sensor for label-free detection of single molecules: thermo-optic vs reactive mechanism | Zendy

S. Arnold | Zendy; S. I. Shopova | Zendy; Stephen Holler | Zendy

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Whispering gallery mode bio-sensor for label-free detection of single molecules: thermo-optic vs reactive mechanism

Author(s) -

S. Arnold,

S. I. Shopova,

Stephen Holler

Publication year - 2009

Publication title -

optics express

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.394

H-Index - 271

ISSN - 1094-4087

DOI - 10.1364/oe.18.000281

Subject(s) - whispering gallery wave , radius , resonator , optics , materials science , wavelength , toroid , q factor , optical power , whispering gallery , optoelectronics , physics , laser , plasma , computer security , quantum mechanics , computer science

Thermo-optic and reactive mechanisms for label-free sensing of bio-particles are compared theoretically for Whispering Gallery Mode (WGM) resonators (sphere, toroid) formed from silica and stimulated into a first order equatorial mode. Although it has been expected that a thermo-optic mechanism should "greatly enhance" wavelength shift signals [A.M. Armani et al, Science 317, 783-787 (2007)] accompanying protein binding on a silica WGM cavity having high Q (10(8)), for a combination of wavelength (680 nm), drive power (1 mW), and cavity size (43 microm radius), our calculations find no such enhancement. The possible reasons for this disparity are discussed.

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