In vitro ovarian tumor growth and treatment response dynamics visualized with time-lapse OCT imaging | Zendy

Conor L. Evans | Zendy; Imran Rizvi | Zendy; Tayyaba Hasan | Zendy; Johannes F. de Boer | Zendy

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In vitro ovarian tumor growth and treatment response dynamics visualized with time-lapse OCT imaging

Author(s) -

Conor L. Evans,

Imran Rizvi,

Tayyaba Hasan,

Johannes F. de Boer

Publication year - 2009

Publication title -

optics express

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.394

H-Index - 271

ISSN - 1094-4087

DOI - 10.1364/oe.17.008892

Subject(s) - optical coherence tomography , ovarian cancer , live cell imaging , preclinical imaging , coherence (philosophical gambling strategy) , in vitro , optical imaging , optics , computer science , biology , cancer , in vivo , physics , cell , microbiology and biotechnology , biochemistry , genetics , quantum mechanics

In vitro three-dimensional models for metastatic ovarian cancer have been useful for recapitulating the human disease. These spheroidal tumor cultures, however, can grow in excess of 1 mm in diameter, which are difficult to visualize without suitable imaging technology.Optical coherence tomography (OCT) is an ideal live imaging method for non-perturbatively visualizing these complex systems. OCT enabled detailed observations of the model at both nodular and cellular levels, revealing growth dynamics not previously observed. The development of a time-lapse OCT system, capable of automated, multidimensional acquisition, further provided insights into the growth and chemotherapeutic response of ovarian cancer.

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