Optimally chirped multimodal CARS microscopy based on a single Ti:sapphire oscillator | Zendy

Adrian F. Pegoraro | Zendy; Andrew Ridsdale | Zendy; Douglas J. Moffatt | Zendy; Yiwei Jia | Zendy; John Paul Pezacki | Zendy; Albert Stolow | Zendy

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Optimally chirped multimodal CARS microscopy based on a single Ti:sapphire oscillator

Author(s) -

Adrian F. Pegoraro,

Andrew Ridsdale,

Douglas J. Moffatt,

Yiwei Jia,

John Paul Pezacki,

Albert Stolow

Publication year - 2009

Publication title -

optics express

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.394

H-Index - 271

ISSN - 1094-4087

DOI - 10.1364/oe.17.002984

Subject(s) - optics , materials science , femtosecond , laser , raman scattering , microscopy , sapphire , chirp , raman spectroscopy , fiber laser , optoelectronics , photonic crystal fiber , wavelength , physics

We demonstrate high performance coherent anti-Stokes Raman scattering (CARS) microscopy of live cells and tissues with user-variable spectral resolution and broad Raman tunability (2500 - 4100 cm(-1)), using a femtosecond Ti:Sapphire pump and photonic crystal fiber output for the broadband synchronized Stokes pulse. Spectral chirp of the fs laser pulses was a user-variable parameter for optimization in a spectral focusing implementation of multimodal CARS microscopy. High signal-to-noise, high contrast multimodal imaging of live cells and tissues was achieved with pixel dwell times of 2-8 micros and low laser powers (< 30 mW total).

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