Open AccessTwo-photon-induced photoluminescence imaging of tumors using near-infrared excited gold nanoshells
Author(s) -
Jaesook Park,
Arnold D. Estrada,
Kelly Sharp,
Krystina L. Sang,
Jon A. Schwartz,
Danielle K. Smith,
Chris L. Coleman,
J. Donald Payne,
Brian A. Korgel,
Andrew K. Dunn,
James W. Tunnell
Publication year - 2008
Publication title -
optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 271
ISSN - 1094-4087
DOI - 10.1364/oe.16.001590
Subject(s) - nanoshell , photoluminescence , materials science , nanorod , luminescence , excited state , colloidal gold , fluorescence , optics , optoelectronics , dielectric , photothermal therapy , nanoparticle , infrared , nanotechnology , plasmon , physics , nuclear physics
Gold nanoshells (dielectric silica core/gold shell) are a novel class of hybrid metal nanoparticles whose unique optical properties have spawned new applications including more sensitive molecular assays and cancer therapy. We report a new photo-physical property of nanoshells (NS) whereby these particles glow brightly when excited by near-infrared light. We characterized the luminescence brightness of NS, comparing to that of gold nanorods (NR) and fluorescent beads (FB). We find that NS are as bright as NR and 140 times brighter than FB. To demonstrate the potential application of this bright two-photon-induced photoluminescence (TPIP) signal for biological imaging, we imaged the 3D distribution of gold nanoshells targeted to murine tumors.
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