Effect of speckles on the depth sensitivity of laser Doppler perfusion imaging | Zendy

Vinayakrishnan Rajan | Zendy; Babu Varghese | Zendy; Ton G. van Leeuwen | Zendy; Wiendelt Steenbergen | Zendy

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Effect of speckles on the depth sensitivity of laser Doppler perfusion imaging

Author(s) -

Vinayakrishnan Rajan,

Babu Varghese,

Ton G. van Leeuwen,

Wiendelt Steenbergen

Publication year - 2007

Publication title -

optics express

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.394

H-Index - 271

ISSN - 1094-4087

DOI - 10.1364/oe.15.010911

Subject(s) - optics , speckle pattern , sensitivity (control systems) , laser doppler velocimetry , doppler effect , coherence (philosophical gambling strategy) , optical coherence tomography , penetration depth , materials science , laser , physics , blood flow , medicine , quantum mechanics , astronomy , electronic engineering , engineering

A theoretical model is presented and experimentally validated that allows the prediction of the effect of speckles on the depth sensitivity of laser Doppler perfusion imaging. It is shown that the influence of speckles on depth sensitivity is large. In particular the sensitivity to particle motion in superficial layers is strongly beam diameter dependent: decreasing the beam diameter on the tissue surface increases the sensitivity to superficial motion to a much stronger extent than sensitivity to motion at a larger depth. This can be explained through the effect of beam diameter changes on the fractional coherence areas generated by photons with different penetration depths in the tissue.

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