Multiphoton plasmon-resonance microscopy | Zendy

Dvir Yelin | Zendy; Dan Oron | Zendy; Stephan Y. Thiberge | Zendy; Elisha Moses | Zendy; Yaron Silberberg | Zendy

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Multiphoton plasmon-resonance microscopy

Author(s) -

Dvir Yelin,

Dan Oron,

Stephan Y. Thiberge,

Elisha Moses,

Yaron Silberberg

Publication year - 2003

Publication title -

optics express

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.394

H-Index - 271

ISSN - 1094-4087

DOI - 10.1364/oe.11.001385

Subject(s) - surface plasmon resonance , optics , microscopy , materials science , second harmonic generation , autofluorescence , plasmon , laser , two photon excitation microscopy , microscope , surface plasmon , nanoparticle , optoelectronics , nanotechnology , physics , fluorescence

A novel method for detection of noble-metal nanoparticles by their nonlinear optical properties is presented and applied for specific labeling of cellular organelles. When illuminated by laser light in resonance with their plasmon frequency these nanoparticles generate an enhanced multiphoton signal. This enhanced signal is measured to obtain a depth-resolved image in a laser scanning microscope setup. Plasmon-resonance images of both live and fixed cells, showing specific labeling of cellular organelles and membranes, either by two-photon autofluorescence or by third-harmonic generation, are presented.

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