In vivo imaging-guided microsurgery based on femtosecond laser produced new fluorescent compounds in biological tissues | Zendy

Qiqi Sun | Zendy; Zhongya Qin | Zendy; Wanjie Wu | Zendy; Yue Lin | Zendy; Congping Chen | Zendy; Sicong He | Zendy; Xuesong Li | Zendy; Zhenguo Wu | Zendy; Yi Luo | Zendy; Jianan Y. Qu | Zendy

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In vivo imaging-guided microsurgery based on femtosecond laser produced new fluorescent compounds in biological tissues

Author(s) -

Qiqi Sun,

Zhongya Qin,

Wanjie Wu,

Yue Lin,

Congping Chen,

Sicong He,

Xuesong Li,

Zhenguo Wu,

Yi Luo,

Jianan Y. Qu

Publication year - 2018

Publication title -

biomedical optics express

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.362

H-Index - 86

ISSN - 2156-7085

DOI - 10.1364/boe.9.000581

Subject(s) - femtosecond , fluorescence , in vivo , laser , fluorescence lifetime imaging microscopy , preclinical imaging , biomedical engineering , microsurgery , materials science , biophysics , optics , biology , medicine , surgery , physics , microbiology and biotechnology

Femtosecond laser microsurgery has become an advanced method for clinical procedures and biological research. The tissue treated by femtosecond laser can become highly fluorescent, indicating the formation of new fluorescent compounds that can naturally label the treated tissue site. We systematically characterized the fluorescence signals produced by femtosecond laser ablation in biological tissues in vivo . Our findings showed that they possess unique fluorescence properties and can be clearly differentiated from endogenous signals and major fluorescent proteins. We further demonstrated that the new fluorescent compounds can be used as in vivo labelling agent for biological imaging and guided laser microsurgery.

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