Imaging brain activity during seizures in freely behaving rats using a miniature multi-modal imaging system | Zendy

Iliya Sigal | Zendy; Margaret M. Koletar | Zendy; Dene Ringuette | Zendy; Raanan Gad | Zendy; Melanie Jeffrey | Zendy; Peter L. Carlen | Zendy; Bojana Stefanovic | Zendy; Ofer Levi | Zendy

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Imaging brain activity during seizures in freely behaving rats using a miniature multi-modal imaging system

Author(s) -

Iliya Sigal,

Margaret M. Koletar,

Dene Ringuette,

Raanan Gad,

Melanie Jeffrey,

Peter L. Carlen,

Bojana Stefanovic,

Ofer Levi

Publication year - 2016

Publication title -

biomedical optics express

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.362

H-Index - 86

ISSN - 2156-7085

DOI - 10.1364/boe.7.003596

Subject(s) - neuroimaging , craniotomy , medicine , neurovascular bundle , blood oxygenation , biomedical engineering , blood flow , functional imaging , cerebral blood flow , radiology , anesthesia , pathology , psychiatry , functional magnetic resonance imaging

We report on a miniature label-free imaging system for monitoring brain blood flow and blood oxygenation changes in awake, freely behaving rats. The device, weighing 15 grams, enables imaging in a ∼ 2 × 2 mm field of view with 4.4 μm lateral resolution and 1 - 8 Hz temporal sampling rate. The imaging is performed through a chronically-implanted cranial window that remains optically clear between 2 to > 6 weeks after the craniotomy. This imaging method is well suited for longitudinal studies of chronic models of brain diseases and disorders. In this work, it is applied to monitoring neurovascular coupling during drug-induced absence-like seizures 6 weeks following the craniotomy.

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