Depth-resolved analytical model and correction algorithm for photothermal optical coherence tomography | Zendy

Maryse Lapierre-Landry | Zendy; Jason M. Tucker-Schwartz | Zendy; Melissa C. Skala | Zendy

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Depth-resolved analytical model and correction algorithm for photothermal optical coherence tomography

Author(s) -

Maryse Lapierre-Landry,

Jason M. Tucker-Schwartz,

Melissa C. Skala

Publication year - 2016

Publication title -

biomedical optics express

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.362

H-Index - 86

ISSN - 2156-7085

DOI - 10.1364/boe.7.002607

Subject(s) - optical coherence tomography , optics , tomography , diffuse optical imaging , algorithm , photothermal therapy , coherence (philosophical gambling strategy) , computer science , physics , quantum mechanics

Photothermal OCT (PT-OCT) is an emerging molecular imaging technique that occupies a spatial imaging regime between microscopy and whole body imaging. PT-OCT would benefit from a theoretical model to optimize imaging parameters and test image processing algorithms. We propose the first analytical PT-OCT model to replicate an experimental A-scan in homogeneous and layered samples. We also propose the PT-CLEAN algorithm to reduce phase-accumulation and shadowing, two artifacts found in PT-OCT images, and demonstrate it on phantoms and in vivo mouse tumors.

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