In vivo optical monitoring of transcutaneous delivery of calcium carbonate microcontainers | Zendy

Elina A. Genina | Zendy; Yulia I. Svenskaya | Zendy; Irina Yu. Yanina | Zendy; Leonid E. Dolotov | Zendy; Nikita Navolokin | Zendy; Alexey N. Bashkatov | Zendy; Georgy S. Terentyuk | Zendy; Alla B. Bucharskaya | Zendy; Gali. Мaslyakova | Zendy; Dmitry A. Gorin | Zendy; Valery V. Tuchin | Zendy; Gleb B. Sukhorukov | Zendy

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In vivo optical monitoring of transcutaneous delivery of calcium carbonate microcontainers

Author(s) -

Elina A. Genina,

Yulia I. Svenskaya,

Irina Yu. Yanina,

Leonid E. Dolotov,

Nikita Navolokin,

Alexey N. Bashkatov,

Georgy S. Terentyuk,

Alla B. Bucharskaya,

Gali. Мaslyakova,

Dmitry A. Gorin,

Valery V. Tuchin,

Gleb B. Sukhorukov

Publication year - 2016

Publication title -

biomedical optics express

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.362

H-Index - 86

ISSN - 2156-7085

DOI - 10.1364/boe.7.002082

Subject(s) - optical coherence tomography , in vivo , materials science , biomedical engineering , nanoparticle , biocompatible material , dermis , nanotechnology , microparticle , laser , drug delivery , optics , pathology , medicine , physics , microbiology and biotechnology , biology

We have developed a method for delivery of biocompatible CaCO3 microcontainers (4.0 ± 0.8 µm) containing Fe3O4 nanoparticles (14 ± 5 nm) into skin in vivo using fractional laser microablation (FLMA) provided by a pulsed Er:YAG laser system. Six laboratory rats have been used for the microcontainer delivery and weekly monitoring implemented using an optical coherence tomography and a standard histological analysis. The use of FLMA allowed for delivery of the microcontainers to the depth about 300 μm and creation of a depot in dermis. On the seventh day we have observed the dissolving of the microcontainers and the release of nanoparticles into dermis.

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