Localization of cortical tissue optical changes during seizure activity in vivo with optical coherence tomography | Zendy

Melissa M. Eberle | Zendy; Mike S. Hsu | Zendy; Carissa L. Rodriguez | Zendy; Jenny I. Szu | Zendy; Michael Oliveira | Zendy; Devin K. Binder | Zendy; B. Hyle Park | Zendy

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Localization of cortical tissue optical changes during seizure activity in vivo with optical coherence tomography

Author(s) -

Melissa M. Eberle,

Mike S. Hsu,

Carissa L. Rodriguez,

Jenny I. Szu,

Michael Oliveira,

Devin K. Binder,

B. Hyle Park

Publication year - 2015

Publication title -

biomedical optics express

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.362

H-Index - 86

ISSN - 2156-7085

DOI - 10.1364/boe.6.001812

Subject(s) - optical coherence tomography , diffuse optical imaging , preclinical imaging , optical imaging , optics , in vivo , optical tomography , coherence (philosophical gambling strategy) , neuroscience , tomography , neuroimaging , physics , biology , microbiology and biotechnology , quantum mechanics

Optical coherence tomography (OCT) is a high resolution, minimally invasive imaging technique, which can produce depth-resolved cross-sectional images. In this study, OCT was used to detect changes in the optical properties of cortical tissue in vivo in mice during the induction of global (pentylenetetrazol) and focal (4-aminopyridine) seizures. Through the use of a confidence interval statistical method on depth-resolved volumes of attenuation coefficient, we demonstrated localization of regions exhibiting both significant positive and negative changes in attenuation coefficient, as well as differentiating between global and focal seizure propagation.

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