Trace cancer biomarker quantification using polystyrene-functionalized gold nanorods | Zendy

Jian Wu | Zendy; Wei Li | Zendy; Ghazal Hajisalem | Zendy; Ariella Lukach | Zendy; Eugenia Kumacheva | Zendy; Fraser Hof | Zendy; Reuven Gordon | Zendy

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Trace cancer biomarker quantification using polystyrene-functionalized gold nanorods

Author(s) -

Jian Wu,

Wei Li,

Ghazal Hajisalem,

Ariella Lukach,

Eugenia Kumacheva,

Fraser Hof,

Reuven Gordon

Publication year - 2014

Publication title -

biomedical optics express

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.362

H-Index - 86

ISSN - 2156-7085

DOI - 10.1364/boe.5.004101

Subject(s) - polystyrene , nanorod , materials science , detection limit , nanotechnology , biomarker , raman scattering , cancer biomarkers , cancer , raman spectroscopy , chemistry , chromatography , polymer , medicine , optics , biochemistry , physics , composite material

We demonstrate the application of polystyrene-functionalized gold nanorods (AuNRs) as a platform for surface enhanced Raman scattering (SERS) quantification of the exogenous cancer biomarker Acetyl Amantadine (AcAm). We utilize the hydrophobicity of the polystyrene attached to the AuNR surface to capture the hydrophobic AcAm from solution, followed by drying and detection using SERS. We achieve a detection limit of 16 ng/mL using this platform. This result shows clinical potential for low-cost early cancer detection.

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