Modified Beer-Lambert law for blood flow | Zendy

Wesley B. Baker | Zendy; Ashwin B. Parthasarathy | Zendy; David R. Busch | Zendy; Rickson C. Mesquita | Zendy; Joel Greenberg | Zendy; Arjun G. Yodh | Zendy

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Modified Beer-Lambert law for blood flow

Author(s) -

Wesley B. Baker,

Ashwin B. Parthasarathy,

David R. Busch,

Rickson C. Mesquita,

Joel Greenberg,

Arjun G. Yodh

Publication year - 2014

Publication title -

biomedical optics express

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.362

H-Index - 86

ISSN - 2156-7085

DOI - 10.1364/boe.5.004053

Subject(s) - beer–lambert law , flow (mathematics) , blood flow , law , computer science , optics , physics , medicine , mechanics , political science

We develop and validate a Modified Beer-Lambert law for blood flow based on diffuse correlation spectroscopy (DCS) measurements. The new formulation enables blood flow monitoring from temporal intensity autocorrelation function data taken at single or multiple delay-times. Consequentially, the speed of the optical blood flow measurement can be substantially increased. The scheme facilitates blood flow monitoring of highly scattering tissues in geometries wherein light propagation is diffusive or non-diffusive, and it is particularly well-suited for utilization with pressure measurement paradigms that employ differential flow signals to reduce contributions of superficial tissues.

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